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CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power

CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power

  • CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power
  • CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power
CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 120511-73-1
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
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Detailed Product Description
Appearance: White Loose Lyophilized Powder. Purity: 99%
Molecular Weight: 334.8854 CAS: 2446-23-3
Molecular Formula: C17H19N5
High Light:

CAS 120511-73-1 Anastrozole Powder

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99% Purity Anastrozole Powder

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C17H19N5 Anastrozole Powder


Anastrozole (arimidex)


Product Name:Anastrozole (arimidex)
CAS : 120511-73-1
Molecular formula: C17H19N5
Molecular weight: 293.37
Appearance: an off-white color crystalline powder

 

DESCRIPTION

ARIMIDEX (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl). Its molecular formula is C17H19N5 and its structural formula is:

 

ARIMIDEX® (anastrozole) Structural Formula Illustration

Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.

Each tablet contains as inactive ingredients: lactose, magnesium stearate, hydroxypropylmethylcellulose, polyethylene glycol, povidone, sodium starch glycolate, and titanium dioxide.

 

INDICATIONS

Adjuvant Treatment

ARIMIDEX is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.

First-Line Treatment

ARIMIDEX is indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer.

Second-Line Treatment

ARIMIDEX is indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Patients with ER-negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to ARIMIDEX.

 

Dosages of Anastrozole:

Dosage Forms and Strengths

Tablet

  • 1 mg

Dosage Considerations – Should be Given as Follows:

Breast Cancer

Postmenopausal women

Advanced

  • 1 mg orally once daily; continue until tumor progression

Early

  • Adjuvant treatment: 1 mg orally once daily; optimal duration unknown; 5 years in clinical trial

Administration

  • May be taken with or without food

Hepatic Impairment

  • Mild-to-moderate impairment or stable hepatic cirrhosis: Dose adjustment not necessary
  • Severe hepatic impairment: Not studied

Pediatric: Use not recommended

 

WHAT ARE WARNINGS AND PRECAUTIONS FOR ANASTROZOLE?

 

Warnings

  • This medication contains anastrozole. Do not take Arimidex if you are allergic to anastrozole or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

Contraindications

  • Hypersensitivity
  • May cause fetal harm or loss; use is contraindicated in women who are or may become pregnant

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Anastrozole?"

Long-Term Effects

  • Decreases lumbar spine and total hipbone mineral density; increased risk of fractures and osteoporosis
  • See "What Are Side Effects Associated with Using Anastrozole?"

Cautions

  • Increased incidence of ischemic cardiovascular events in women with preexisting ischemic heart disease; use only if benefits greatly outweigh risks
  • Decreases lumbar spine and total hipbone mineral density; increased risk of fractures and osteoporosis
  • Elevated serum cholesterol reported; monitor closely
  • Affords no clinical benefit to premenopausal women with breast cancer
  • Increased risk of ischemic cardiovascular events in patients with pre-existing ischemic cardiac disease

Pregnancy and Lactation

  • Do not use anastrozole in pregnancy. The risks involved outweigh potential benefits. Safer alternatives exist
  • It is unknown whether anastrozole is excreted in milk; it is not recommended given potential for serious adverse reactions in nursing infants

 

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CAS 120511-73-1 Anastrozole Arimidex 99% Purity C17H19N5 White Power 1

 
 

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