TOP PHARM CO.,LIMITED

About Us
Factory Tour
Quality Control
Contact Us
Home ProductsHuman Growth Hormone Peptide

99% Purity DSIP CAS 62568-57-4 Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP

99% Purity DSIP CAS 62568-57-4 Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP

  • 99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP
  • 99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP
  • 99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP
99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 62568-57-4
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
Contact Now
Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 62568-57-4
MF: C35H48N10O15 MW: 848.81
High Light:

DSIP Lyophilized Powder

,

Delta Sleep-Inducing Peptide Powder

DSIP

DSIP Unit Size :2 mg/vial
DSIP Unit Quantity :1 Vial
DSIP Purity: 99.0%min
Delta sleep-inducing peptide(DSIP)
Sequence:r-l-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification: 2mg/vial;
CAS#: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Place of Origin: China
Standard: USP
Certification: SGS
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.


Sleep Inducing Peptide DSIP effects :
DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia. DSIP also significantly altered bilateral symmetry of EEG.

DSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS.

 

Delta-sleep-inducing peptide

From Wikipedia, the free encyclopedia
 
 
 
Jump to navigationJump to search
Delta-sleep-inducing peptide
 
Identifiers
Symbol DSIP
UniProt P01158

Delta-sleep-inducing peptide (DSIP) is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Its amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). The gene has yet to be found in rabbits, along with any receptors or precursor peptides. However, searches through BLAST have found that it aligns with a hypothetical Amycolatopsis coloradensis protein. This could indicate that DSIP has a bacterial origin.[2]

Discovery[edit]

Delta-sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.[3]

DSIP-like material has been found in human breast milk.[4]

Structure and interactions[edit]

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C[5]

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[6] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.[5]

In the brain its action may be mediated by NMDA receptors.[7] In another study delta-sleep-inducing peptide stimulated acetyltransferase activity through α1 receptors in rats.[8] It is unknown where DSIP is synthesized.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.[9] It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,[10] but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.[11]

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).[12] GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.[13]

Function[edit]

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability[14] and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.[15]

Roles in endocrine regulation[edit]

Roles in physiological processes[edit]

Roles in disease and medicine[edit]

  • It has been found to have anticarcinogenic properties. In a study on mice, injecting a preparation of DSIP over the mice's lifetime decreased total spontaneous tumor incidence 2.6-fold.[31]
  • The same study found it to also have geroprotective effects: it slowed down the age-related switching-off of oestrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells and it increased by 24.1% maximum life span in comparison with the control group.
  • Levels of DSIP may be significant in patients diagnosed with major depressive disorder (MDD). In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients.[11][32][33]
  • Studies have demonstrated a direct link between GILZ expression (homologous to DSIP) and adipogenesis which has links to obesity and metabolic syndrome.[34]
  • In studies on rats with metaphit-induced epilepsy DSIP acted as an anticonvulsant, significantly decreasing the incidence and duration of fits suggesting DSIP as a potential treatment for epilepsy.[35][36]
  • DSIP has been found to have an analgesic effect. In studies on mice it was found to have a potent antinociceptive effect when administered intracerebroventricularly or intracisternally (see: Route of administration).[37]
  • Due to its possible effects on sleep and nociception, trials have been carried out to determine whether DSIP can be used as an anaesthetic. One such study found that administration of DSIP to humans as an adjunct to isoflurane anaesthesia actually increased the heart rate and reduced the depth of anaesthesia instead of deepening it as expected.[38]
  • Low plasma concentrations of DSIP have been found in patients with Cushing's syndrome.[39]
  • In Alzheimer's patients levels of DSIP have been found to be slightly elevated, though this is unlikely to be causal.[40]
  • A preparation of DSIP, Deltaran, has been used to correct central nervous system function in children after antiblastomic therapy. Ten children aged 3–16 years were given a ten-day course of Deltaran and their bioelectric activity recorded. It was found that the chemotherapy-induced impairment in the bioelectrical activity of 9 out of the 10 children was reduced by administration of DSIP.[41]
  • DSIP can act antagonistically on opiate receptors to significantly inhibit the development of opioid and alcohol dependence and is currently being used in clinical trials to treat withdrawal syndrome.[42][43] In one such trial it was reported that in 97% of opiate-dependent and 87% of alcohol-dependent patients the symptoms were alleviated by DSIP administration.[44]
  • In some studies administration of DSIP has alleviated narcolepsy and normalized disturbed sleeping patterns.[45][46]

Safety and possible side-effects of long-term DSIP use haven't been established in clinical research studies.

 

Polypeptide Hormones we supply
Melanotan II CAS 121062-08-6 timulate the body's tanning response
Selank CAS 129954-34-3 help enhance mental sharpness,enhance memory
DSIP CAS 62568-57-4 Delta sleep-inducing peptide, abbreviated DSIP
Gonadotropin CAS 71447-49-9 Mainly used for prostate cancer
Tesamorelin CAS 218949-48-5 used in the treatment of HIV-associated lipodystrophy
Triptorelin CAS 57773-63-4 used as the acetate or pamoate salts
HG 176-191   the fat-reducing effects
Pentadecapeptide BPC 157 CAS 137525-51-0 increasing lean muscular tissue mass, reducing fat
TB500 CAS 77591-33-4 oincrease muscle growth
Oxytocin CAS 50-56-6 used for stimulation of uterus contractions
Sermorelin CAS 86168-78-7 Increases the development of lean body mass
Hexarelin CAS 140703-51-1 the treatment of growth hormone secretion deficiency
Ipamorelin CAS 170851-70-4 a selective growth hormone secretagogue
Melanotan 1 CAS 75921-69-6 endogenous melanocortine peptide
MGF   used by bodybuilders and athletes
PEG-MGF   cause site specific muscle growth
CJC-1295 Without DAC CAS 863288-34-0 increasing binding affinity to the GHRH receptors
CJC-1295 with DAC CAS 863288-34-0 improved physique and sense of well being
PT-141   increase libido effects of both men and women
GHRP-2 CAS 158861-67-7 growth hormone stimulation
GHRP-6 CAS 87616-84-0 Increase in strength,Muscle mass,Body fat loss
Tb-500 CAS 77591-33-4 increases in endurance,strength and muscle growth

 

 

 

 

 

 

99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP 0

 

Our Service
Fast Delivery Delivery within 24 hours upon receipt of your payment
Quality Quality can be promised. Hot sell to Worldwide
Payment Terms T/T Bank Transfer, Western Union, Paypal, Bitcoin and MoneyGram Available
Sample Sample available at any time

What's APP

+86  18627186113
Package Professional packing with professional materials

 
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we accept bank transfer,Western Union and
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location.For small order,please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.For mass order,please allow 5-8 days by Air, 20-35 days by Sea.
Q7:Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship
Q8:Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.

 

Testosterone cypionate is a prescription drug. It comes as an injectable solution given into the muscle. Testosterone cypionate is a self-injectable drug. You can give this medication to yourself at home after your doctor shows you how to do so.

Testosterone cypionate is available as the brand-name drug Depo-Testosterone. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Testosterone cypionate is a controlled substance. This means it’s regulated by the government.


 
 99% Purity  DSIP CAS 62568-57-4  Lyophilized Powder Delta Sleep-Inducing Peptide Abbreviated DSIP 1

Contact Details
TOP PHARM CO.,LIMITED

Contact Person: Baron

Tel: +8618627186113

Send your inquiry directly to us (0 / 3000)