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99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment

99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment

  • 99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment
  • 99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment
  • 99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment
  • 99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment
99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 112809-51-5
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
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Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 73-78-9
MF: C14H23ClN2O MW: 270.801
High Light:

Chronic Pain Treatment Lidocaine Hydrochloride Powder

,

Steroids Lidocaine Hydrochloride Powder

Letrozole


Alias: Femara , Letrozoles ,TROZET
Dosage: LETROZOLES TABLETS USP 2.5MG
Assay: 98.0-102.0%. USP32
CAS: 112809-51-5
Usage: Anti estrogen
Appearance: White crystalline powder.
Active life cycle : 6 hours
MW: 285.3
MP: 181-183 degrees


 

 

Letrozole

 

From Wikipedia, the free encyclopedia
 
 
 
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Letrozole
 
 
Clinical data
Trade names Femara, others
AHFS/Drugs.com Monograph
MedlinePlus a698004
License data
Routes of
administration
By mouth
Drug class Aromatase inhibitor; Antiestrogen
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 99.9%
Protein binding 60%, mainly to albumin
Metabolism pharmacologically-inactive metabolites Bis(4-cyanophenyl)methanol and 4,4'-dicyanobenzophenone.[3]
Elimination half-life 2 days[3]
Excretion Kidneys[3]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.200.357 Edit this at Wikidata
Chemical and physical data
Formula C17H11N5
Molar mass 285.310 g·mol−1
3D model (JSmol)
(verify)

Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer.

It was patented in 1986 and approved for medical use in 1996.

Medical uses[edit]

Breast cancer[edit]

 
Femara 2.5 mg oral tablet

Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.

Comparison with tamoxifen[edit]

Tamoxifen is also used to treat hormonally-responsive breast cancer, but it does so by interfering with the estrogen receptor. However, letrozole is effective only in post-menopausal women, in whom estrogen is produced predominantly in peripheral tissues (i.e. in adipose tissue, like that of the breast) and a number of sites in the brain.In pre-menopausal women, the main source of estrogen is from the ovaries not the peripheral tissues, and letrozole is ineffective.

In the BIG 1–98 Study, of post-menopausal women with hormonally-responsive breast cancer, letrozole reduced the recurrence of cancer, but did not change survival rate, compared to tamoxifen.

Ovulation induction[edit]

Letrozole has been used for ovulation induction by fertility doctors since 2001, because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation.[citation needed] A study of 150 babies following treatment with either letrozole alone or letrozole and gonadotropins presented at the American Society of Reproductive Medicine 2005 Conference found no difference in overall abnormalities but did find a significantly higher rate of locomotor and cardiac abnormalities among the group having taken letrozole compared to natural conception.A larger, follow-up study with 911 babies compared those born following treatment with letrozole to those born following treatment with clomiphene. That study also found no significant difference in the rate of overall abnormalities, but found that congenital cardiac anomalies was significantly higher in the clomiphene group compared to the letrozole group. Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole's makers to approve the drug for infertility in India and also stated that letrozole's use for infertility was illegal worldwide;however, such off-label uses are legal in many countries such as the US and UK.

Contraindications

Letrozole is contraindicated in women having a pre-menopausal hormonal status, during pregnancy and lactation.

Side effects

The most common side effects are sweating, hot flashes, arthralgia (joint pain), and fatigue.

Generally, side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is in certain patient populations such as post-menopausal women or osteoporotics, bisphosphonates may also be prescribed.[citation needed]

Interactions

Letrozole inhibits the liver enzyme CYP2A6, and to a lesser extent CYP2C19, in vitro, but no relevant interactions with drugs like cimetidine and warfarin have been observed.

 

 

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99% Purity Lidocaine Hydrochloride CAS 73-78-9 White Powder Chronic Pain Treatment 8

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