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99% Purity Betamethasone CAS 378-44-9 White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma

99% Purity Betamethasone CAS 378-44-9 White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma

  • 99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma
  • 99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma
  • 99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma
  • 99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma
99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 378-44-9
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
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Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 378-44-9
MF: C22H29FO5 MW: 392.46
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Betamethasone
CAS: 378-44-9
MF: C22H29FO5
MW: 392.46
EINECS: 206-825-4
mp 235-237°C
refractive index 118 ° (C=1, Dioxane)
storage temp. 0-6°C
Chemical Properties White to Off-White Solid
Usage Glucocorticoid
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum


 

 

Betamethasone

 

From Wikipedia, the free encyclopedia
 
 
 
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Betamethasone
Clinical data
Trade names Celestone, Eleuphrat, others
AHFS/Drugs.com Monograph
MedlinePlus a682799
License data
Pregnancy
category
Routes of
administration
By mouth, topical, intramuscular (IM)
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Liver CYP3A4
Elimination half-life 36-54 hours
Excretion Kidney (in urine)
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.006.206 Edit this at Wikidata
Chemical and physical data
Formula C22H29FO5
Molar mass 392.461 g·mol−1
3D model (JSmol)
(verify)

Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby's lungs, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others.It can be taken by mouth, injected into a muscle, or applied to the skin topically in cream, lotion, or liquid forms.

Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis. Long-term use may cause adrenal insufficiency. Stopping the medication suddenly following long-term use may be dangerous. The cream commonly results in increased hair growth and skin irritation. Betamethasone belongs to the glucocorticoid class of medication. It is a stereoisomer of dexamethasone, the two compounds differing only in the spatial configuration of the methyl group at position 16 (see steroid nomenclature).

Betamethasone was patented in 1958, and approved for medical use in the United States in 1961. The cream and ointment are on the World Health Organization's List of Essential Medicines.It is available as a generic medication. In the United States, the pills and injectable solutions are more expensive than the cream.

Medical uses

Betamethasone is a corticosteroid that is available as a pill, by injection, and as an ointment, cream, lotion, gel, or aerosol (spray) for the skin, and a foam for the scalp.When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.

It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination calcipotriol/betamethasone dipropionate. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals include the steroid as the valerate ester.

In a randomized controlled trial betamethasone was shown to reduce some of the ataxia (poor coordination) symptoms associated with ataxia telangiectasia (A-T) by 28-31%.

Betamethasone is also used to stimulate fetal lung maturation in order to prevent infant respiratory distress syndrome (IRDS) and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys and often averts the need for circumcision.It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.

Side effects[edit]

Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds, or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.

Betamethasone is also used prior to delivery of a preterm baby to help prepare the lungs for breathing. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.

When injected into the epidural space or the spine, it may cause serious side effects like loss of vision, stroke, and paralysis.[18]

Forms[edit]

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort (in Pakistan), and others), betamethasone sodium phosphate (branded as Bentelan in Italy) and betamethasone valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid (branded as Diprosalic) for using in psoriatic skin conditions. In some countries, it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.

Betamethasone sodium phosphate mixed with betamethasone acetate is available in the United States as Celestone Soluspan.

 

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99% Purity Betamethasone CAS 378-44-9  White powder Treatment of rheumatic diseases,dermatitis andcowhide moss asthma 8

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