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99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation

99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation

  • 99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation
  • 99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation
  • 99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation
  • 99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation
99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 129938-20-1
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Minimum Order Quantity: 10g
Price: Negotiable
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Delivery Time: 3-6 working days
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Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 129938-20-1
MF: C21H23NO MW: 341.88
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Dapoxetine HCl
 
 
Chemical Names: Dapoxetine HCl; Dapoxetine hydrochloride;
CAS No.: 129938-20-1
Molecular Weight: 341.88
Molecular Formula: C21H23NO HCL
Assay: 99%min
Appearance: White crystalline powder
 

Dapoxetine

 

From Wikipedia, the free encyclopedia
 
 
 
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Dapoxetine
Clinical data
Trade names EJ-30, Priligy, others (see below)
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral (tablets)
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 15–76% (mean 42%), Tmax = 1–1.3 hours
Protein binding >99%
Metabolism Liver (CYP2D6, CYP3A4), kidney (FMO1)
Metabolites Dapoxetine-N-oxide, desmethyldapoxetine, didesmethyldapoxetine
Elimination half-life 1.5–1.6 h
Excretion Kidneys[1]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C21H23NO
Molar mass 305.421 g·mol−1
3D model (JSmol)

Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. As a member of the selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant.

Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Dapoxetine is sold in several European and Asian countries, and in Mexico. In the US, dapoxetine has been in phase III development. In May 2012, USA-based Furiex Pharmaceuticals reached an agreement with ALZA Corp and Janssen Pharmaceutica to market dapoxetine in the USA, Japan, and Canada, while selling the rights to market the drug in Europe, most of Asia, Africa, Latin America, and the Middle East to Menarini.

Medical uses

Premature ejaculation

Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosages have different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but no difference is seen in men with acquired PE.Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition.With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when dapoxetine is used.However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido.Dapoxetine, though, is generally categorized as a fast-acting SSRI. It is more rapidly absorbed and mostly eliminated from the body within a few hours. These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, and side effects.

Depression and anxiety

Although it was initially thought of as unsuccessful in its intended use as an antidepressant, dapoxetine has been more recently investigated as a possible aid to one approach to depression treatment focused on stress reduction, based on an animal model of depression.As of October 2018, dapoxetine is listed as an SSRI used to treat depression and anxiety by the UK's NHS.

Contraindications

Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycin. Dapoxetine also cannot be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressants. If a patient stops taking one of these drugs, he should wait for 14 days before taking dapoxetine. If a patient stops taking dapoxetine, he should wait for 7 days before receiving these drugs.

 

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99% Purity Dapoxetine HCl CAS 129938-20-1 White powder Pharmacological treatment of premature ejaculation 1

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