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99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder thyroid hormone physiological

99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder thyroid hormone physiological

  • 99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder  thyroid hormone  physiological
  • 99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder  thyroid hormone  physiological
99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder  thyroid hormone  physiological
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 55-06-1
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
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Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 55-06-1
MF: C15H11I3NNaO4 MW: 690.9706
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T3 L-Triiodothyronine

Quick Detail:
T3 L-Triiodothyronine
1 ) CAS NO : 55-06-1
2 ) EINECS : 200-223-5
3 ) Chemical name : 3,3',5-Triiodo-L-thyronine, sodium salt
4 ) Molecular formula : C15H11I3NNaO4
5 ) Molecular Weight : 690.9706
6 ) Assay : 99%
7 ) Boiling point : 205 ℃
9 ) Usage : It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate, such as, treatment of depressive disorders and use as a fat loss supplement.

 

Triiodothyronine

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Triiodothyronine
Names
IUPAC name
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
Other names
triiodothyronine
T3
3,3′,5-triiodo-L-thyronine
Identifiers
3D model (JSmol)
2710227
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.027.272 Edit this at Wikidata
EC Number
  • 229-999-3
KEGG
UNII
Properties
C15H12I3NO4
Molar mass 650.977 g·mol−1
Hazards
GHS labelling:
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
NFPA 704 (fire diamond)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the anterior pituitary gland. This pathway is part of a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the anterior pituitary gland. As concentrations of these hormones decrease, the anterior pituitary gland increases production of TSH, and by these processes, a feedback control system stabilizes the level of thyroid hormones in the bloodstream.

T3 is the true hormone. Its effects on target tissues are roughly four times more potent than those of T4.[2] Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the liver and anterior pituitary by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. The half-life of T3 is about 2.5 days.[3] The half-life of T4 is about 6.5 days.

Production

Synthesis from T4

 
Thyroid hormone synthesis, with the end-product of triiodothyroninе seen at bottom right.[5]

T3 is the more metabolically active hormone produced from T4. T4 is deiodinated by three deiodinase enzymes to produce the more-active triiodothyronine:

  1. Type I present in liver, kidney, thyroid, and (to a lesser extent) pituitary; it accounts for 80% of the deiodination of T4.
  2. Type II present in CNS, pituitary, brown adipose tissue, and heart vessel, which is predominantly intracellular. In the pituitary, it mediates negative feedback on thyroid-stimulating hormone.
  3. Type III present in placenta, CNS, and hemangioma. This deiodinase converts T4 into reverse T3, which, unlike T3, is inactive.

T4 is synthesised in the thyroid follicular cells as follows.

  1. The sodium-iodide symporter transports two sodium ions across the basement membrane of the follicular cells along with an iodine ion. This is a secondary active transporter that utilises the concentration gradient of Na+ to move I against its concentration gradient.
  2. I is moved across the apical membrane into the colloid of the follicle.
  3. Thyroperoxidase oxidises two I to form I2. Iodide is non-reactive, and only the more reactive iodine is required for the next step.
  4. The thyroperoxidase iodinates the tyrosyl residues of the thyroglobulin within the colloid. The thyroglobulin was synthesised in the ER of the follicular cell and secreted into the colloid.
  5. Thyroid-stimulating hormone (TSH) released from the anterior pituitary gland binds the TSH receptor (a Gs protein-coupled receptor) on the basolateral membrane of the cell and stimulates the endocytosis of the colloid.
  6. The endocytosed vesicles fuse with the lysosomes of the follicular cell. The lysosomal enzymes cleave the T4 from the iodinated thyroglobulin.
  7. These vesicles are then exocytosed, releasing the thyroid hormones.
 
Synthesis of T3 from T4 via deiodination. Synthesis of reverse T3 and T2 is also shown.
 

Direct synthesis

 

The thyroid gland also produces small amounts of T3 directly. In the follicular lumen, tyrosine residues become iodinated. This reaction requires hydrogen peroxide. Iodine bonds carbon 3 or carbon 5 of tyrosine residues of thyroglobulin in a process called organification of iodine. The iodination of specific tyrosines yields monoiodotyrosine (MIT) and diiodotyrosine (DIT). One MIT and one DIT are enzymatically coupled to form T3. The enzyme is thyroid peroxidase.

The small amount of T3 could be important because different tissues have different sensitivities to T4 due to differences in deiodinase ubiquitination in different tissues link. This once again raises the question if T3 should be included in thyroid hormone replacement therapy

99% Purity T3 L-Triiodothyronine CAS 55-06-1 White powder  thyroid hormone  physiological 11

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