TOP PHARM CO.,LIMITED

About Us
Factory Tour
Quality Control
Contact Us
Home ProductsOral Anabolic Steroids

99% Purity 2 , 4-Dinitrophenol CAS 51-28-5 organic compound It is a yellow, crystalline solid that has a sweet

99% Purity 2 , 4-Dinitrophenol CAS 51-28-5 organic compound It is a yellow, crystalline solid that has a sweet

  • 99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet
  • 99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet
  • 99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet
  • 99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet
99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 51-28-5
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
Contact Now
Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 51-28-5
MF: C6H4N2O5 MW: 184.11
High Light:

organic oral steroids

,

bodybuilding oral anabolic steroids

DNP

2 , 4-Dinitrophenol

1. CAS No: 51-28-5
2. MF: C6H4N2O5
3. MW: 184.11
4. Purity: 99%
5. Package: discreet packing way with your choice
6. Appearance: Buff monoclinic crystal. Soluble in hot water, ethanol,acetone, benzene, chloroform and pyridine insoluble in cold water. Can with water vapor volatilization, heated sublimation.

 

2,4-Dinitrophenol

 
 
 
 
Jump to navigationJump to search

 

2,4-Dinitrophenol
Sample of pure compound
Names
Preferred IUPAC name
2,4-Dinitrophenol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.000.080 Edit this at Wikidata
KEGG
UNII
UN number 0076Dry or wetted with less than 15% water. Class 1.1D explosives
1320Wetted with not less than 15% water. DT Solid desensitized explosives, toxic
1599Toxic solution
Properties
C6H4N2O5
Molar mass 184.107 g·mol−1
Density 1.683 g/cm3
Melting point 108–112 °C (226–234 °F; 381–385 K)
Acidity (pKa) 4.114
-73.1·10−6 cm3/mol
Hazards
GHS labelling:
Danger
H201, H300, H311, H331, H372, H400
P261, P273, P280, P301+P310, P311
NFPA 704 (fire diamond)
Safety data sheet (SDS) International Chemical Safety Card 0464
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions.[1] When in a dry form, it is a high explosive and has an instantaneous explosion hazard.It is a precursor to other chemicals and is biochemically active, uncoupling oxidative phosphorylation from the electron transport chain in cells with mitochondria, by allowing protons to pass from the intermembrane space into the mitochondrial matrix. Oxidative phosphorylation is a highly regulated step in aerobic respiration that is inhibited, among other factors, by normal cellular levels of ATP. Uncoupling it results in chemical energy from diet and energy stores such as triglycerides being wasted as heat with minimal regulation, leading to dangerously high body temperatures that may develop into heatstroke. Its use as a dieting aid has been identified with severe side-effects, including a number of deaths.

Uses

Commercially, DNP is used as an antiseptic and as a non-selective bioaccumulating pesticide.

DNP is particularly useful as a herbicide alongside other closely related dinitrophenol herbicides like 2,4-dinitro-o-cresol (DNOC), dinoseb and dinoterb. Since 1998 DNP has been withdrawn from agricultural use. Currently, there are no actively registered pesticides containing DNP in the United States or Europe. Dinoseb is used industrially as a polymerisation inhibitor during styrene production.

It is a chemical intermediate in the production of sulfur dyes, wood preservatives[4] and picric acid.DNP has also been used to make photographic developers and explosives (see shellite). DNP is classified as an explosive in the United Kingdom and the United States.

Although DNP is widely considered too dangerous for clinical use, its mechanism of action remains under investigation as a potential approach for treating obesity.[14] As of 2015, research is being conducted on uncoupling proteins naturally found in humans.[15]

Biochemistry[edit]

In living cells, DNP acts as a proton ionophore, an agent that can shuttle protons (hydrogen cations) across biological membranes. It dissipates the proton gradient across the mitochondria membranes, collapsing the proton motive force that the cell uses to produce most of its ATP chemical energy. Instead of producing ATP, the energy of the proton gradient is lost as heat.

DNP is often used in biochemistry research to help explore the bioenergetics of chemiosmotic and other membrane transport processes.

Mechanism of action

DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat. The inefficiency is proportional to the dose of DNP that is taken. As the dose increases and energy production is made more inefficient, metabolic rate increases (and more fat is burned) in order to compensate for the inefficiency and to meet energy demands. DNP is probably the best known agent for uncoupling oxidative phosphorylation. The "phosphorylation" of adenosine diphosphate (ADP) by ATP synthase gets disconnected or "uncoupled" from oxidation.

From the Journal of Clinical Toxicology, Volume 44, Issue 3 (2006):

Dinitrophenol uncouples oxidative phosphorylation, causes release of calcium from mitochondrial stores and prevents calcium re-uptake. This leads to free intracellular calcium and causes muscle contraction and hyperthermia. Dantrolene inhibits calcium release from the sarcoplasmic reticulum which reduces intracellular calcium. The resulting muscle relaxation allows heat dissipation. There is little risk to dantrolene administration. Since dantrolene may be effective in reducing hyperthermia caused by agents that inhibit oxidative phosphorylation, early administration may improve outcome.[16]

Pharmacokinetics

Information about pharmacokinetics of DNP in humans is limited.]The ATSDR's Toxicological Profile for Dinitrophenols remarks that DNP elimination appears to be rapid except when liver function is impaired. The NEJM remarks that DNP appears to be eliminated in around three to four days, except possibly when the liver and kidneys are damaged. Other papers give a wide array of possible half-lives, ranging from 3 hours to 5–14 days, while still other, more recent papers maintain that the half-life in humans is unknown.

 

 

 

 

 

 

 

 

99% Purity 2 , 4-Dinitrophenol CAS 51-28-5   organic compound   It is a yellow, crystalline solid that has a sweet 11

Contact Details
TOP PHARM CO.,LIMITED

Contact Person: Baron

Tel: +8618627186113

Send your inquiry directly to us (0 / 3000)