TOP PHARM CO.,LIMITED

About Us
Factory Tour
Quality Control
Contact Us
Home ProductsCaine Series Pharmaceutical Raw Materials

CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist

CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist

  • CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist
  • CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist
  • CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist
  • CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist
CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 4956-37-0
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: bulk stock
Contact Now
Detailed Product Description
Purity: 99% Appearance: White Loose Lyophilized Powder.
Spec: 10G CAS: 4956-37-0
MF: C25H36O3 MW: 384.556
High Light:

CAS 4956-37-0 Estradiol Enanthate Powder

,

Estrogen Receptors Estradiol Enanthate Powder

Product Description:
Estradiol Enanthate
CAS Number: 4956-37-0
Purity: 99.5%
Molecular Weight: 384.556
Molecular Formula: C25H36O3
Appearance: Crystalline powder
Physical State: Solid
Solubility: Soluble in water (slightly).
Storage: Store at room temperature
Melting Point: 94-96 ° C
Boiling Point: ~509.5 ° C at 760 mmHg (Predicted)
Density: ~1.1 g/cm3 (Predicted)

 

Estradiol enantate (EEn or E2-EN), also spelled estradiol enanthate and sold under the brand names Perlutal and Topasel among others, is an estrogen medication which is used in hormonal birth control for women.It is formulated in combination with dihydroxyprogesterone acetophenide (DHPA; algestone acetophenide), a progestin, and is used specifically as a combined injectable contraceptive. Estradiol enantate is not available for medical use alone.The medication, in combination with DHPA, is given by injection into muscle once a month.

Side effects of estradiol enantate include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[16] Estradiol enantate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.It is an estrogen ester and a long-lasting prodrug of estradiol in the body. Because of this, it is considered to be a natural and bioidentical form of estrogen.

Estradiol enantate was first described by 1954,and was first studied in combination with DHPA as a combined injectable contraceptive in 1964.The combination was introduced for clinical use by the mid-1970s.Estradiol enantate is not available as a standalone medication (i.e., by itself without DHPA).The combination is available in Latin America and Hong Kong, and was also previously marketed in Spain and Portugal

Medical uses

Estradiol enantate is used in combination with the progestin DHPA as a once-monthly combined injectable contraceptive for women in Latin America and Hong Kong.[1][2][24][15] Estradiol enantate has been studied in feminizing hormone therapy for transgender women as well.[25] The combination of estradiol enantate and DHPA has likewise been used by transgender women for such purposes

Pharmacodynamics

Estradiol enantate is an estradiol ester, or a prodrug of estradiol.[5][6] As such, it is an estrogen, or an agonist of the estrogen receptors.[5][6] Estradiol enantate is of about 41% higher molecular weight than estradiol due to the presence of its C17β enantate ester.Because estradiol enantate is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen.

The combination of 10 mg estradiol enantate and 150 mg DHPA as a once-monthly combined injectable contraceptive (which achieves levels of estradiol of around 350 pg/mL)has been found to have little to no effect on many markers of estrogen-modulated liver protein synthesis, including circulating levels of HDL and LDL cholesterol, copper, ceruloplasmin, total and free cortisol, corticosteroid-binding globulin, and sex hormone-binding globulin.[44][45] However, it was found to significantly increase levels of triglycerides and to significantly decrease levels of total and free testosterone.In contrast to the estradiol enantate-containing combined injectable contraceptive, low-dose ethinylestradiol-containing birth control pills produce highly significant changes in all of the preceding parameters.

Studies in women and female capuchin monkeys have found that injections of estradiol enantate and DHPA significantly alter levels of coagulation factors.

The clinical estrogenic effects of estradiol enantate and ethinylestradiol have been compared in other studies as well

Pharmacokinetics

When estradiol enantate is administered in an oil solution by intramuscular injection, a depot effect occurs, and this results in it having a long duration of action.[10][6][49] The duration of action of estradiol enantate is considerably longer than that of various other estradiol esters, such as estradiol benzoate, estradiol valerate, and estradiol cypionate, whereas its duration is shorter than that of estradiol undecylate.[10][50][51] In general, the longer the fatty acid ester chain, the more lipophilic the estradiol ester, the more slowly it is released from the depot and absorbed into the circulation, and the longer its duration of action.[6][49]

The pharmacokinetics of estradiol enantate have been assessed in a number of studies. It has usually been studied in combination with DHPA. Following an intramuscular injection of estradiol enantate, levels of estradiol have been found to peak after 3 to 8 days. Maximal levels of estradiol after a 5 mg injection of estradiol enantate have been found to be about 163 to 209 pg/mL and after a 10 mg injection of estradiol enantate have been found to be about 283 to 445 pg/mL. However, one outlying study reported peak estradiol levels of 850 pg/mL after an intramuscular injection of 10 mg estradiol enantate in three postmenopausal women. It used radioimmunoassay for the determinations, with no mention of chromatographic separation. Estradiol levels following an intramuscular injection of 10 mg estradiol enantate have been found to return to baseline levels of around 50 pg/mL after about 20 to 30 days. However, a metabolic study found that traces of radiolabeled estradiol enantate remained detectable in blood for at least 30 to 40 days and for as long as 60 days.Studies have reported that the elimination half-life of estradiol enantate after a single 10 mg intramuscular injection was 5.6 to 7.5 days.The volume of distribution of estradiol enantate has been reported to be 5.087 L.Estradiol enantate is excreted preferentially in urine.

There were concerns about possible accumulation of estradiol enantate and consequent estrogenic overexposure with once-monthly combined injectable contraceptives containing the medication due its long duration, and this may have limited the use of such combined injectable contraceptives. Subsequent clinical studies have found that there is very limited or no accumulation of estradiol enantate when it is used in once-a-month injectable contraceptives

 

 
 

 

 

 

 


CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist 0
 

Our Service
Fast Delivery Delivery within 24 hours upon receipt of your payment
Quality Quality can be promised. Hot sell to Worldwide
Payment Terms T/T Bank Transfer, Western Union, Paypal, Bitcoin and MoneyGram Available
Sample Sample available at any time

What's APP

+86  18627186113
Package Professional packing with professional materials

 
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we accept bank transfer,Western Union and
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location.For small order,please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.For mass order,please allow 5-8 days by Air, 20-35 days by Sea.
Q7:Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship
Q8:Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.

 

Testosterone cypionate is a prescription drug. It comes as an injectable solution given into the muscle. Testosterone cypionate is a self-injectable drug. You can give this medication to yourself at home after your doctor shows you how to do so.

Testosterone cypionate is available as the brand-name drug Depo-Testosterone. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Testosterone cypionate is a controlled substance. This means it’s regulated by the government.
 
 CAS 4956-37-0 99% Purity Estradiol Enanthate Powder Estrogen Receptors Agonist 1

Contact Details
TOP PHARM CO.,LIMITED

Contact Person: Baron

Tel: +8618627186113

Send your inquiry directly to us (0 / 3000)