Metabolic syndrome
Studies show DHEA helps reduce abdominal fat and improve insulin resistance. Other studies suggest that DHEA helps reduce inflammation in the arteries and reduce arterial stiffness.
Heart disease
Studies link low DHEA levels with an increase in heart disease. Researchers aren't sure whether supplementing with DHEA is safe or reduces risk.
Systemic lupus erythematosus (SLE)
Lupus or SLE is an autoimmune disorder. That means that the body's immune system mistakenly attacks its own tissue. Several studies show that taking DHEA along with other medications helps improve quality of life for people with lupus, though it probably does not change the overall course of their disease.
Several studies have found that some people who take DHEA supplements may be able take less prescription medication. DHEA may also reduce the frequency of flare ups, enhance mental function, and boost bone mass in women with lupus. Many studies use 200 mg per day of DHEA, which can raise levels of testosterone and lower HDL ("good") cholesterol. One study found that a lower dose -- 20 to 30 mg -- might also work. Most of these studies have been small. So more studies are needed to determine whether DHEA is safe and effective for people with lupus.
Adrenal insufficiency
DHEA is one of the hormones made by the adrenal glands. With adrenal insufficiency, the adrenal glands do not make enough hormones, including DHEA and cortisol. That happens either because of problems with the pituitary gland or damage to the adrenal glands themselves (also called Addison's disease).
Several studies suggest that taking DHEA may help improve mood, fatigue, and well being. In one study, women with this condition who took DHEA supplements reported improved sexuality and sense of well being, including fewer feelings of depression and anxiety.
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