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CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry

CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry

  • CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry
  • CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry
  • CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry
  • CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry
CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 62-44-2
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Minimum Order Quantity: 10g
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Detailed Product Description
Appearance: White Crystalline Solid Purity: 99%
CAS NO: 62-44-2 Molecular Formula: C10H13NO2
MW: 179.22
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CAS 62-44-2 Phenacetin Pharmaceutical Raw Materials

Phenacetin

CAS number: 62-44-2
Molecular Formula: C10H13NO2

Monoisotopic mass: 179.094635 Da

 

penacetin is a synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen.

 

The painkiller phenacetin was the world's first synthetic pharmaceutical drug. It was developed by an American chemist and began distribution in 1887. Phenacetin was often accompanied by aspirin and caffeine in what were called APC pills, which were widely distributed during and after World War II. The use of phenacetin in the U.S. was discontinued in the 1980s because of links to cancer and other adverse side effects, but it remains available in some countries.

Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.

In 1983, the U.S. Food and Drug Administration (FDA) banned phenacetin in the U.S. because of its discovered carcinogenic properties and its link to kidney failure. The FDA stated that phenacetin alone is reasonably believed to be a human carcinogen, or cancer-causing agent, and that painkiller mixtures containing the drug are known human carcinogens. There has been little evidence found that phenacetin alone is a human carcinogen because it usually has been administered in combination with other drugs.

 

Description

Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

IC50 & Target

COX-3

102 μM (IC50)

In Vitro

Phenacetin shows inhibitory activity for COX-3 with an IC50 value of 102 μM in insect cells [1].
Phenacetin is a substrate widely used as an in vitro and in vivo probe to measure the activity of CYP1A2, because the metabolism of phenacetin to acetaminophen is thought to be a selective CYP1A2-mediated reaction[2][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phenacetin exhibits elimination half-life (rat 2.06 h) and Cmax (6,728.3 μg/L) following oral administration (rat 20 mg/kg)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (180-200 g)[2]
Dosage: 20 mg/kg
Administration: Oral administration (Pharmacokinetic Analysis)
Result: T1/2 (2.06 hours), Cmax (6,728.3 μg/L).
Molecular Weight

179.22

Formula

C10H13NO2

CAS No.
SMILES

CC(NC1=CC=C(OCC)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

 

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CAS 62-44-2 Phenacetin Raw Materials Crystalline Solid For Pharmaceutical Industry 0

 

 

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