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CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide Powder For Building Muscle

CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide Powder For Building Muscle

  • CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide  Powder For Building Muscle
  • CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide  Powder For Building Muscle
CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide  Powder For Building Muscle
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 87616-84-0
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Minimum Order Quantity: 10g
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Delivery Time: 3-6 working days
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Detailed Product Description
Appearance: White Powder Purity: 99%
CAS NO: 87616-84-0 Molecular Formula: C46H56N12O6
Molecular Weight: 873.01
High Light:

GHRP-6 Growth Hormone Releasing Peptide

,

Bodybuilding Peptides Acetate Powder

GHRP-6 Acetate
 
 
Product Name GHRP-6 Acetate
Sequence
Cas No. 87616-84-0
Molecular Formula C46H56N12O6
Molecular Weight 873.01
Purity (HPLC) 98.0%min.
Appearance? White powder
Single Impurity (HPLC)? 1.0%max
Amino Acid Composition? ±10% of theoretical
Peptide Content (N%) ?≥80.0%
Water Content(Karl Fischer)? ≤6.0%
Acetate Content (HPIC) ≤12.0%
MS(ESI) Consistent
Mass Balance  95.0~105.0%
 
Description: GHRP-6 acetate is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (Ibutamoren) to COS-7 cell membranes expressing human GHS-R type Ia and binding of ghrelin to COS-7 cells expressing human GHS-R. GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor and inositol phosphate production in COS-7 cells expressing the human receptor. It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland. It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.

 

Amino Acid Sequence

His-Trp-Lys-Trp-Phe-Lys-NH2

General description

[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.

Application

[D-Lys3]-GHRP-6 has been used:
  • to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
  • as an antagonist of growth hormone secretagogue receptor (GHS-R)
  • as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)

 GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.1,2,3,4 It inhibits binding of the GHS-R agonist MK-0677 to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).2,3 GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).3 It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.1 It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.4

References
1. Bowers, C.Y., Momany, F.A., Reynolds, G.A., et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114(5), 1537-1545 (1984).
2. Howard, A.D., Feighner, S.D., Cully, D.F., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273(5277), 974-977 (1996).
3. Holst, B., Brandt, E., Bach, A., et al. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol. Endocrinol. 19(9), 2400-2411 (2005).
4. Wren, A.M., Small, C.J., Ward, H.L., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141(11), 4325-4328 (2000).

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CAS 87616-84-0 GHRP-6 Acetate Growth Hormone Releasing Peptide  Powder For Building Muscle 0

 

 

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