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99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0

99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0

  • 99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0
  • 99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0
99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 159519-65-0
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: As your requirments
Delivery Time: 3-6 working days
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Supply Ability: bulk stock
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Detailed Product Description
Appearance: White Powder Purity: 99%
CAS NO: 159519-65-0 Molecular Formula: C204H301N51O64
Molecular Weight: 4492
High Light:

99% Purity Enfuvirtide Acetate

,

Enfuvirtide Acetate Peptide Powder

Product Name Enfuvirtide Acetate (T-20)
Sequence CH3CO-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu
-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-
Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys
-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Cas No. 159519-65-0
Molecular Formula C204H301N51O64
Molecular Weight 4492
Purity (HPLC) 98.0%min.
Appearance? White to off-white amorphous solid
Single Impurity (HPLC)? 0.5%max
Amino Acid Composition? ±10% of theoretical
Peptide Content (N%) ≥80.0%
Water Content (Karl Fischer)? ≤8.0%
TrifluoroAcetate Content(HPIC) ≤12.0%
MS (ESI) Consistent
Mass Balance  95.0~105.0%

 

Description Enfuvirtide is an anti-HIV-1 fusion inhibitor peptide. Sequence: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2.
Related Catalog
Target HIV fusion[1]
In Vitro A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM[2]. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide[3].
In Vivo Enfuvirtide has a T1/2 of 3.8 h[2].
Solvent
In Vitro:

10 mM in DMSO
Solubility
1 mM 0.2226 mL 1.1131 mL 2.2262 mL
5 mM 0.0445 mL 0.2226 mL 0.4452 mL
10 mM 0.0223 mL 0.1113 mL 0.2226 mL
Animal Admin For infection with the resistant HIV strains, 7-day-cultured macrophages (105 cells/well in 96-well plates) are incubated with or without IFN-λ1, λ2, or λ3 (100 ng/mL each) and/or anti-HIV drugs: Azidothymidine (AZT) 10 pM; Efavirenz 100 pM; Indinavir 10-3 pM, and Enfuvirtide 10 nM for 24 h. Cells are then infected with different strains of HIV (6 ng p24/well) for 2 h. After washed three times with plain DMEM, cells are cultured with fresh 10% DMEM containing IFN-λs and/or antiretroviral drugs. For HIV Bal infection, culture supernatant is harvested at day 8 post infection for RT and p24 assays. Infected and untreated cells served as controls. HIV Gag gene expression in infected cells is also examined at day 8 post infection. For anti-HIV drug-resistant virus (A012 G691-6 or TC49) infection, culture supernatant is harvested for HIV p24 protein by ELISA at days 3, 5, 7, and 10 postinfection. The cell cultures are replaced with the fresh media supplemented with IFN-λ1, λ2, or λ3 and/or the antiretrovirals every 2–3 days. The culture supernatant collected at day 10 postinfection is also subjected to RT assay[3].
Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
References

[1]. Figueira TN, et al. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance. Sci Rep. 2017 Mar 30;7:45647.

[2]. Cao P, et al. The improved efficacy of Sifuvirtide compared with Enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance. PLoS One. 2017 Feb 16;12(2):e0171567.

[3]. Wang X, et al. IFN-λ Inhibits Drug-Resistant HIV Infection of Macrophages. Front Immunol. 2017 Mar 6;8:210.
Related Molecules Cenicriviroc | Ebselen | Triciribine | Raltegravir (potassium salt) | Tipranavir | DELAVIRDINE MESYLATE | Bictegravir | TAK-779 | Betulinic acid |

 Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).

 

Enfuvirtide is a synthetic peptide derived from a naturally occurring amino acid sequence in the HR2 domain of GP41. By simulating the activity of the HR2 domain and competitively binding the HR1 domain of GP41, it prevents the interaction between HR1 and HR2 and changes in gp41 configuration, thus preventing the fusion of virus and host cells. Similar to most peptide drugs, the likelihood of metabolic drug interactions with enfveitide is low.

 

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99% Purity Enfuvirtide Acetate T-20 Peptide Powder CAS159519-65-0 0

 

 

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Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.

Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
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Q3: Do you Accept Sample Order?
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A:It is Depending on your location.For small order,please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.For mass order,please allow 5-8 days by Air, 20-35 days by Sea.

Q7:Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship

Q8:Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.

 

 

 

 

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