TOP PHARM CO.,LIMITED
|Place of Origin:||China|
|Brand Name:||Top Pharm|
|Minimum Order Quantity:||10g|
|Packaging Details:||As your requirments|
|Delivery Time:||3-6 working days|
|Payment Terms:||T/T, Western Union, MoneyGram,bitcoin|
|Supply Ability:||bulk stock|
|CAS NO:||159519-65-0||Molecular Formula:||C204H301N51O64|
99% Purity Enfuvirtide Acetate,
Enfuvirtide Acetate Peptide Powder
|Description||Enfuvirtide is an anti-HIV-1 fusion inhibitor peptide. Sequence: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2.|
|In Vitro||A cell-cell fusion assay reveals that the effective concentration for achieving 50% inhibition (IC50) of Enfuvirtide is 23 ± 6 nM. IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz, Indinavir, and Enfuvirtide) significantly inhibita the expression of HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3) also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz, Indinavir, and Enfuvirtide.|
|In Vivo||Enfuvirtide has a T1/2 of 3.8 h.|
|Animal Admin||For infection with the resistant HIV strains, 7-day-cultured macrophages (105 cells/well in 96-well plates) are incubated with or without IFN-λ1, λ2, or λ3 (100 ng/mL each) and/or anti-HIV drugs: Azidothymidine (AZT) 10 pM; Efavirenz 100 pM; Indinavir 10-3 pM, and Enfuvirtide 10 nM for 24 h. Cells are then infected with different strains of HIV (6 ng p24/well) for 2 h. After washed three times with plain DMEM, cells are cultured with fresh 10% DMEM containing IFN-λs and/or antiretroviral drugs. For HIV Bal infection, culture supernatant is harvested at day 8 post infection for RT and p24 assays. Infected and untreated cells served as controls. HIV Gag gene expression in infected cells is also examined at day 8 post infection. For anti-HIV drug-resistant virus (A012 G691-6 or TC49) infection, culture supernatant is harvested for HIV p24 protein by ELISA at days 3, 5, 7, and 10 postinfection. The cell cultures are replaced with the fresh media supplemented with IFN-λ1, λ2, or λ3 and/or the antiretrovirals every 2–3 days. The culture supernatant collected at day 10 postinfection is also subjected to RT assay.|
|Shipping||Room temperature in continental US; may vary elsewhere|
|Related Molecules||Cenicriviroc Ebselen Triciribine Raltegravir (potassium salt) Tipranavir DELAVIRDINE MESYLATE Bictegravir TAK-779 Betulinic acid|
Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).
Enfuvirtide is a synthetic peptide derived from a naturally occurring amino acid sequence in the HR2 domain of GP41. By simulating the activity of the HR2 domain and competitively binding the HR1 domain of GP41, it prevents the interaction between HR1 and HR2 and changes in gp41 configuration, thus preventing the fusion of virus and host cells. Similar to most peptide drugs, the likelihood of metabolic drug interactions with enfveitide is low.
|Trenbolone acetate(Finaplix H/Revalor-H)||10161-34-9|
|Drostanolone enanthate(masteron enanthate)||472-61-1|
|Drostanolone proplonate(masteron propioante)||521-12-0|
|Fast Delivery||Delivery within 24 hours upon receipt of your payment|
|Quality||Quality can be promised. Hot sell to Worldwide|
|Payment Terms||T/T Bank Transfer, Western Union, Paypal, Bitcoin and MoneyGram Available|
|Sample||Sample available at any time|
|Package||Professional packing with professional materials|
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we accept bank transfer,Western Union and
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location.For small order,please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.For mass order,please allow 5-8 days by Air, 20-35 days by Sea.
Q7:Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship
Q8:Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
Contact Person: Anne