CAS 16789-98-3 Desmopressin Acetate Peptide Powder For Building Muscle

Von Willebrand Disease (Type 1)

• Indicated for patients with mild to moderate classic von Willebrand’s disease (Type I) with factor VIII levels greater than 5%
• 0.3 mcg/kg IV over 15-30 minutes (for pre-op, 30 min before procedure)

Intranasal (Stimate)

• Indicated for patients with mild to moderate classic von Willebrand disease (Type I) with Factor VIII levels >5%
• <50 kg: 150 mcg; for pre-op, give 2 hr before procedure
• Indication

  • Indicated for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void (intranasal).

  • Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region (intranasal/parenteral).

  • Indicated for patients with hemophilia A with factor VIII coagulant activity levels greater than 5% or mild to moderate classic von Willebrand's Disease (Type I) with factor VIII levels greater than 5% during surgical procedures and postoperatively to maintain hemostasis (parenteral).

  >50 kg: 300 mcg; for pre-op, give 2 hr before procedure

Mechanism of action

Upon binding of desmopressin to V2 receptors in the basolateral membrane of the cells of the distal tubule and collecting ducts of the nephron, adenylyl cyclase is stimulated. The resulting intracellular cascades in the collecting duct lead to increased rate of insertion of water channels, called aquaporins, into the lumenal membrane and enhanced the permeability of the membrane to water

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