TOP PHARM CO.,LIMITED
|Place of Origin:||China|
|Brand Name:||Top Pharm|
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Androsterone 1 Dehydroepiandrosterone,
C19H30O2 1 Dehydroepiandrosterone,
CAS 53-41-8 1 Dehydroepiandrosterone
Product Name: Androsterone 1-Dehydroepiandrosterone
CAS No.: 53-41-8
Melting Point: 181-184℃
Appearance: White or white crystalline powder
DHEA is one of the most abundant steroid hormones in the human body. It is produced by the adrenal glands, the gonads, and the brain. It is normally found in the form ofdehydroepiandrosterone sulfate (DHEAS). The body holds DHEAS in reserve and converts it to specific hormones when needed.
Tetrahydrogestrinone (THG) is a steroid recently identified to be misused as doping agent. However, the knowledge on functions of this substance in humans or animal models is rather limited. Therefore, it was our aim to further characterize the pharmacological profile of THG and identify potential adverse side effects. THG was synthesized, the purity was confirmed and its biological activity was tested. The potency of THG to transactivate AR dependent reporter gene expression was two orders of magnitude lower compared to dihydrotestosterone. THG binds with high affinity but unselective to the androgen (AR), progesterone (PR), glucocorticoid (GR) and mineralocorticoid (MR) receptor. Treatment of orchiectomised rats with THG resulted in a stimulation of prostate, seminal vesicle and levator ani muscle, indicating androgenic and anabolic properties. In the liver THG, in contrast to testosteronepropionate (TP), down regulates the expression of the GR dependent tyrosine aminotransferase gene (TAT). In summary, our results demonstrate that THG is not a specific AR agonist. THG exhibits a high binding affinity to all tested steroid hormone receptors and binds with highest affinity to the GR. Our in vivo data are indicative of an anabolic and androgenic potency of THG, but the repression of TAT demonstrates that THG also interferes with the glucocorticoid hormone system. Therefore, it is conceivable that an intake will result in adverse side effects.
Be cautious with this combination
The body changes DHEA to estrogen in the body. Anastrozole (Arimidex) is used to help decrease estrogen in the body. Taking DHEA along with anastrozole (Arimidex) might decrease the effectiveness of anastrozole (Arimidex). Do not take DHEA if you are taking anastrozole (Arimidex).
The body changes DHEA to estrogen in the body. Exemestane (Aromasin) is used to help decrease estrogen in the body. Taking DHEA along with exemestane (Aromasin) might decrease the effectiveness of exemestane (Aromasin). Do not take DHEA if you are taking exemestane (Aromasin).
Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Fulvestrant (Faslodex) is used for this type of estrogen cancer. DHEA might increase estrogen in the body and decrease the effectiveness of fulvestrant for treating cancer. Do not take DHEA if you are taking fulvestrant
|Trenbolone acetate(Finaplix H/Revalor-H)||10161-34-9|
|Drostanolone enanthate(masteron enanthate)||521-12-0|
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