99% Pharmaceutical Raw Materials Cabergoline/Caber/Dostinex CAS 81409-90-7 white powder

Cabergoline

Alias: Cabaser, Dostinex; Dostine, 6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
CAS: 81409-90-7
Molecular Formula: C26H37N5O2
Molecular Weight: 451.6
Melting Point: 102-104° C

Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.

DOSTINEX Tablets, for oral administration, contain 0.5 mg of cabergoline. Inactive ingredients consist of leucine, USP, and lactose, NF.

Cabergoline is used to treat different types of medical problems that occur when too much of the hormone prolactin is produced. It can be used to treat certain menstrual problems, fertility problems in men and women, and pituitary prolactinomas (tumors of the pituitary gland).

It works by stopping the brain from making and releasing the prolactin hormone from the pituitary gland. Cabergoline use is usually stopped when prolactin levels are normal for 6 months. It may be given again if symptoms of too much prolactin occur again.

This medicine is available only with your doctor's prescription.

Biochem/physiol Actions
Cabergoline, a lysergic acid amide derivative, is a potent dopamine D2 receptor agonist. It also acts on dopamine receptors in lactophilic hypothalamus cells to suppress prolactin production in the pituitary gland. It has been used for monotherapy of Parkinson′s disease in the early phase; combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson′s disease and adjunctive therapy of prolactin-producing pituitary gland tumors (microprolactinomas).
Features and Benefits

Cabergoline dosing information

Usual Adult Dose for Hyperprolactinemia:

Initial dose: 0.25 mg orally twice a week
-Increase dose in increments of 0.25 mg twice a week no more frequently than every 4 weeks according to patient's prolactin level
Maximum dose: 1 mg twice a week

Comments:
-Patients should be maintained on the lowest dose that provides maximal response.
-After maintaining normal serum prolactin levels for 6 months, this drug may be stopped and serum prolactin levels followed to determine whether reinitiating therapy is necessary.

Use: For the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas.