CAS 5630-53-5 Tibolone White Or Yellow Powder Muscle Growth Hormone , Oral Anabolic Steroid

Tibolone

CAS Number: 5630-53-5
Formula: C21H28O2
Molar mass: 312.446 g/mol
Description: white or yellow white crystalline powder

Tibolone is a synthetic steroid with weak estrogenic, progestogenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptors. It is a prodrug of several metabolites. The estrogenic effects of tibolone may show tissue selectivity in their distribution.

Who can use tibolone?

Tibolone can be used by women who have an intact uterus and have not experienced a natural period for at least one year. If taken sooner, irregular bleeding may be experienced. Women can also transition from cyclical, or combined continuous MHT onto Tibolone. Tibolone has the same contraindications as any oral combined MHT.

Side-effects of tibolone

Side-effects may include headache, dizziness, nausea, abdominal pain, swollen feet and itching. Breast tenderness is uncommon. Slight bleeding or spotting may commonly occur initially but tends to subside after a few months. Amenorrhoea is achieved by about 80% of women after the first month of treatment with tibolone and over 90% after the third month of therapy (10).

Safety of tibolone

• In the LIFT study of tibolone for the prevention of bone loss and osteoporotic fractures, there was an increase in stroke in the tibolone group compared with the placebo group (4). This was mainly seen in women over 60 years of age. The increase among women in their 50s was 4 extra cases per 1000 and among women in their 60s, an extra 13 cases per 1000 women.
• Tibolone decreases total and LDL cholesterol and triglyceride levels. However, it also decreases HDL cholesterol. The impact of these changes on cardiovascular events is not clear. Meta-analysis of only four studies examining this showed a non-significant odds ratio for cardiovascular events with tibolone of 1.38 [ 0.84, 2.27 ] (2).
• The data on breast safety have been contradictory. Preclinical data on tibolone concentrated on its effect on oestrogen metabolism in the breast. Tibolone and its metabolites reduce sulfatase and stimulate sulfotransferase activity thereby inhibiting the formation of active