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Dapoxetine hydrochloride Male Enhancement Steroids CAS 129938-20-1

Dapoxetine hydrochloride Male Enhancement Steroids CAS 129938-20-1

  • Dapoxetine hydrochloride Male Enhancement Steroids   CAS 129938-20-1
  • Dapoxetine hydrochloride Male Enhancement Steroids   CAS 129938-20-1
Dapoxetine hydrochloride Male Enhancement Steroids   CAS 129938-20-1
Product Details:
Place of Origin: China
Brand Name: Top Pharm
Certification: IOS 901
Model Number: 129938-20-1
Payment & Shipping Terms:
Minimum Order Quantity: 10g
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Detailed Product Description
Appearance: White Or White Crystalline Powder Other Names: Dapoxetine Hydrochloride
Purity: 99% CAS: 129938-20-1
MF: C21H23NO HCL MW: 341.88
High Light:

male sex hormones

,

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99% purity Male Pharmaceutical raw materials HCl CAS 129938-20-1 White powder
 
Chemical Names: HCl; hydrochloride;
CAS No.: 129938-20-1
Molecular Weight: 341.88
Molecular Formula: C21H23NO HCL
Assay: 99%min
Appearance: White crystalline powder
 
Applications:
 
Treat male premature ejaculation and erectile dysfunction. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.
 
 
Abstract
Premature ejaculation (PE) is a common male sexual disorder which is associated with substantial personal and interpersonal negative psychological consequences. Pharmacotherapy of PE with off-label antidepressant selective serotonin reuptake inhibitors (SSRIs) is common, effective and safe. Development and regulatory approval of drugs specifically for the treatment of PE will reduce reliance on off-label treatments and serve to fill an unmet treatment need. The objective of this article is to review evidence supporting the efficacy and safety of in the treatment of PE. MEDLINE, Web of Science, PICA, EMBASE and the proceedings of major international and regional scientific meetings were searched for publications or abstracts published during the period 1993–2012 that used the word ‘’ in the title, abstract or keywords. This search was then manually cross referenced for all papers. This review encompasses studies of pharmacokinetics, animal studies, human phase I, II and III studies, independent postmarketing and pharmacovigilance efficacy and safety studies and drug-interaction studies. is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact. It is rapidly absorbed and eliminated, resulting in minimal accumulation, and has dose-proportional pharmacokinetics which are unaffected by multiple dosing. 30 mg and 60 mg has been evaluated in five industry-sponsored randomized, double-blind, placebo-controlled studies in 6081 men aged at least 18 years. Outcome measures included stopwatch-measured intravaginal ejaculatory latency time (IELT), Premature Ejaculation Profile (PEP) inventory items, Clinical Global Impression of Change (CGIC) in PE, and adverse events. Mean IELT, all PEP items and CGIC improved significantly with both doses of versus placebo (all p <0.001). The most common treatment-related adverse effects included nausea (11.0% for 30 mg, 22.2% for 60 mg), dizziness (5.9% for 30 mg, 10.9% for 60 mg), and headache (5.6% for 30 mg, 8.8% for 60 mg), and evaluation of validated rated scales demonstrated no SSRI class-related effects with use. , as the first drug developed for PE, is an effective and safe treatment for PE and represents a major advance in sexual medicine.

 

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